1. Lateralization of headache.
2. Blood-brain barrier.
3. Plasma glutamate cannot freely cross the BBB.
4. Plasma magnesium cannot freely cross the BBB.
5. Cortical spreading depression till today (10 December 2018) has not been recorded in the normal, non-injured human brain.
6. Cortical spreading depression has a well-established neuro-protective, perhaps, best seen in the locust.
7. 100 years of erroneous thinking and research data and Opinion are very likely liable to be wiped out.
8. Cortical neuronal hyperactivity is generated by AMITRIPTYLINE (TRICYCLIC ANTIDEPRESSANTS), a well-established first-line agent for prevention of migraine since 1975-78.
9. Blind persons do not experience photophobia or the classical scintillating scotomata (SS).
10. Migraine headache or SS does not develop in enucleated eyes.
11. Neuro-pharmacologically, migraine and cluster headache and other variants of primary headaches cannot originate in the brain parenchyma or meninges.
12. PFO is an adaptive mechanism in migraine pathophysiology.
13. Why despite universal or at least global non-metabolic non-oxidative physical and psychical stress, 80 percent of the human population does not develop migraine attacks?
14. How and why does a migraine attack start and stop by itself?
15 Why does vomiting relieve the migraine headache frequently?
16. Tissue-creep underlies remissions and exacerbations in primary headaches, as detailed to the Rolex Awards Committee, Bern, Switzerland, in 1989.
My repeated attempts since 1990 to put these facts across have been stymied by reviewers and editors who form part of the collective herd in neuro-ophthalmology in late 20-early 21 Century.
New Delhi 10 December 2018
ORCiD ID: 0000-0002-6770-5619
Dear Vinod
interesting list of questions! Not all of them have the same importance or interest but I agree that we don't know much about migraine mechanisms and that several hypothesis - some of them you're mentioning - are not really substantiated. You could have add the question of the vascular implication in migraine...
best,
Christophe
Dear Christophe:
A good beginning is a good beginning. Well begun is half done.
At least we have a few true intellectuals in our midst.
The rest are disguised as scientists with their statistically significant data that biologically mean zilch.
Best
Vinod
Just Kipling's six honest serving men (and women) are required for all human endeavours; the rest of humanity tries its best not to let them on stage.
- Badges
- Science topic