This need was felt as way back as 1990-1992 by two leading researchers / scientists, one of whom was the then Chief-Editor for the journal Headache.
As is very common in human endeavour, nobody wants to acknowledge error or going up the wrong road or the wrong tree, whether it is a military or civil matter, legal or non-legal, within or outside marriage or live-in or teen-crush... The best that might come through is settlement with a large wad of cash, as is common with the Industry, without admitting to anything. Acknowledging error is fatal to the the ego of the individual, the Organisation, or the Country or The World, as we know it.. Equally appropriate is the fact that scientific or any other wisdom will not slide into your own persona unless you make space for it by shedding your ego, your extant understanding, and your shame.
Well, scientific research is a bit different. It requires you to be honest, it is frustating (Jerome P. Kassirer, N Engl J Med 1993, 328: 1634-1636), it requires a clearly preconceived idea (Claude Bernard (mid-1800s), careful phrasing of the research question (Medawar, 1979), no divorce from logic (Popper), academic freedom and integrity (Lancet 342 (8879): 1993:1063-1064), BMJ 306, 17th April, 1076), freedom to pursue truth without regard to cost or immediate utility (James McCormick)...
Nothing like this has been done for migraine research. All the moneys spent on research grants has produced scientific literature -- sideways progress, that I call lateral progress not lateral thinking -- but no advance in our comprehension of migraine as an entity. Such thinking creates foresight to see through the haze that envelops migraine research.
But what is the truth? Data do not lie, but in the absence of an integrating theoretical matrix, they create several versions of the truth in true democratic fashion. Medicine and medical research, however, is not democratic -- ultimately, there is only version of the truth. Is it statistical or something that can gleaned with high-technology -- both having been applied freely without any restraint in migraine research, and, without any success.
Or is it jettisoning of the big ideas of the past that are now entrenched and non-performing and are holding up progress (see attachment)?
Or is it imagination--that can, if applied properly, conquer all worlds (see attachment)?
Or is it more reflection and contemplation ( a la Sir Francis Bacon: "...the human understanding, when it has once adopted an opinion...either neglects or despises or else by some distinction sets aside (...the contrary opinion)."
Or is it an act of creativity that is sustained over decades of hammering by new ideas and new evidences, and, simply keeps growing in scientific stature and in the underlying science (Rolex Awards, 1989)(see attachment)?
Please let me know if these references/sites are helpful to you:
1. An update on migraine: current understanding and future directions
...
https://link.springer.com/article/10.1007/s00415-017-8434-y
An update on migraine: current understanding and future directions ... MigrainePathophysiology Treatment CGRP Neuromodulation. Download fulltext PDF.
2. Pathophysiology of Migraine: Current Status and Future Directions
https://link.springer.com/content/pdf/10.1007/978-3-319-15621-7_11.pdf
An understanding of migraine pathophysiology must encom- pass the varied clinical
3. Pathophysiology of Migraine: Current Status and Future Directions
...
New directions in migraine - CiteSeerX
http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=5BFD69A53615C4C9D554F881DCA5F4C7?doi=10.1.1.288.4331&rep=rep1&type=pdfJun 10, 2011 ...
New directions in migraine. Greg A Weir and M ... understanding of migraine, which was initially ... affect the future of migraine neurobiology and therapy. ... in migraine pathogenesis, as evidenced by the expression pattern of ...
4. New directions in migraine | BMC Medicine | Full Text
https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-9-116Oct 25, 2011 ...
New directions in migraine .... glutamate in the brain, a neurotransmitter heavily implicated in migraine pathogenesis [29]. .... The multigenic nature of migraine lends itself to the idea that multiple ... Summary and future directions ...
12916_2011_466_MOESM1_ESM.pdf
Authors' original file for figure 1.
5. Migraine: Pathophysiology, Pharmacology, Treatment and Future ...
https://notendur.hi.is/meb1/wikiverk/migraine_pathophysiology%20pharmacology%20treatment%20and%20future%20trends.pdf
Migraine: Pathophysiology, Pharmacology, Treatment and Future Trends. Carlos M. Villalón* .... of migraine in view that all acute
Dennis
Dennis Mazur
Dennis:
At first, a thank you for your interest.
As the one in the forefront of migraine research since almost three decades with the conceptual breakthrough coming my way in 1974, let me clarify that these 5 references are old wine in old bottles. These are routine publications from Tertiary Headache Research Centres in the fervent hope that they will carry through the next generation, and, that nobody will think through the breakthrough.
I will detail in my next question what is required to move forward in migraine research.
For the sake of future generations of researchers -- as well as the current young ones with warm blood in their circulation, sharp new eyes, and skills of a new Century -- and the supremely confident conviction that the Internet or other forms of Artificial Intelligence will never fail them -- I add that the these forms of information clog the thinking process and do not allow your motive or your intent to crystallise. I have been there and have seen it all.
A quote from the epilogue of my book, page 70: Adaptive Mechanisms in Migraine. Nova Science, New York, 2009: "If I have climbed a personal Everest, it has been without oxygen, and more importantly, without gloves or footwear."
The Internet can provide oxygen only to the prepared mind. The eyes refuse to register and the mind turns turtle when the oxygen is offered on the platter of tenure and finance and less noble motives. The muses of fame and glory are forever watching over the pretenders of today and tomorrow.
Vinod
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