Step 1. Ability to clear the deadwood, the clutter on the table, the myth and assumptions that constitute "truth" for several generations. You have to be a demolition expert. To deconstruct to reconstruct with your own publications, of course. Such quality publications come once in a generation or a century or a millennium or several millennia.
Step 2. Ability to withstand a tsunami of counter-intellectual attacks. Original research is an insurrection. Insurrection is an art, and like all arts it has its laws--L. Trotsky. All insurrections and discoveries come at a breakpoint of discontent.
The inventor of the wheel and fire and cloth and paper in its present form and the mattress and so many other facets that contribute to modern living comforts remain anonymous.
When you can surmount and go beyond the muse of fame and fortune, Nature smiles upon you to release one or more of its closely guarded secrets.
The aim is not to win the prize but to discover new knowledge for the benefit of all of humankind.
Motive is more important than method. Dennis P. Burkitt (BMJ, 1993).