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Questions related from Vinod Kumar Gupta
Technology has curbed the prowess of critical thinking by the brain. What next, after wastage of quintillions - trillions or dollars / Euros for over 100 years by gadgeteers / device-loving...
31 May 2024 9,547 0 View
I have had the misfortune to see a quadriplegic female aged 11 years with severe spasticity ++++ following asphyxia due to laryngeal spams and cerebral anoxia growing up with her disability...
27 May 2024 6,843 1 View
For anything we do not understand in medicine and medical therapy, including acute migraine attacks, we therapists use corticosteroids in the garb of rescue therapy. Why? Only at ResearchGate is...
19 May 2024 9,168 8 View
An important component of the now-neglected formal neurological examination worldwide, what with MRI/CT/MRI Angiography/PET, technology has limited critical thinking skills and acceptance of new...
18 May 2024 8,292 0 View
Abdominal pain is or can anytime become a deep mystery that challenges the best minds. I have a case to share that will give immersive insight but was refused for Publication as a snippet by the...
18 May 2024 8,104 0 View
I address a huge missing gap in clinical Medicine, as currently practiced. With specialization in multiple disciplines in Medicine, blood sugar and diabetes mellitus come to the fore only if...
09 October 2023 5,102 1 View
Migraine research commonly turns altruism on its head, upside down. Just like an inebriated person tries different keys to open the same lock, the history of migraine is replete with examples of...
14 August 2023 2,232 0 View
Nasal visual field involvement has never been documented in migraine-linked scintillating scotomata. In a dedicated search of migraine literature spanning almost 50 years, I have never found a...
06 August 2023 779 0 View
The tsunami of RCT in migraine has plateaued, if not subsided, after the CGRT-monoclonal antibody bandwagon has completed its role by early 2019 in the ongoing theatre of migraine research. The...
28 March 2019 3,304 4 View
Zugzwang is a German word which translates to "compulsion to move." There comes a time in chess, when moving your piece is fatal to your game, and, not-to-move is not an option that you might...
04 March 2019 8,479 1 View
Why scientists must share their failures Failure moves research forwards 4th May 2017 We don’t ask people in other professions to do it, but it’s vital for speeding up progress in crucial areas of...
10 January 2019 2,463 9 View
1. Lateralization of headache. 2. Blood-brain barrier. 3. Plasma glutamate cannot freely cross the BBB. 4. Plasma magnesium cannot freely cross the BBB. 5. Cortical spreading depression till...
10 December 2018 3,374 3 View
ROS are produced as a natural byproduct of normal metabolism and play an important role in cell signaling and homeostasis (Moris et al. 2017). Since around the last decade, there has been a...
05 December 2018 600 1 View
The time has come," the Walrus said, "To talk of many things: Of shoes--and ships--and sealing-wax-- Of cabbages--and kings-- And why the sea is boiling hot-- And whether pigs have wings." The...
30 November 2018 8,456 16 View
Are we creatures of electricity? How does the transformation of a unknown dimension transform itself into a known commodity that is utilized by the human / non-human creatures that abound on Earth...
28 November 2018 1,122 3 View
The biological role of peripheral and cortical alterations of glutamate and glutamine in migraine pe-ictally, during, and in-between headache attacks is uncertain. The role of glutamate in the...
28 November 2018 6,391 0 View
Glutamate has attracted lot of attention in neuroscience and migraine research. It is time to come to grips with this issue.
28 November 2018 7,902 7 View
As Medical practitioners, we all deal with several patients/people every day. How many of us are good listeners? And how many us are pushers, pigeon-holing patients swiftly and sometimes...
26 November 2018 2,701 7 View
Seven decades ago, cortical spreading depression was detected by chance, Leao became a hero, and many so-called heroes in migraine research climbed upon the band-wagon, hoping to convert...
01 September 2018 3,851 1 View
What are the socio-cultural, educational, political, legal and punitive, moral, evolutionary, psycho-psychiatric-transformational, sexual fanciful reasons for such horrendous male behaviour?...
15 August 2018 9,502 1 View
03 AUGUST 2018 NATURE Gigantic review of German science recommends more data and diversity Big data and diversity lacking at Germany’s biggest science organization.
09 August 2018 9,600 1 View
Hypoxemia from patent foramen ovale in a 65-year-old woman with carcinoid heart disease Chengyue Yang and Aditya Sharma CMAJ August 07, 2018 190 (31) E933-E936; DOI:...
07 August 2018 1,023 0 View
May, might, can, could, seemingly, apparently, perhaps, possibly, proposed, expectedly, unexpectedly, surprisingly, unsurprisingly, presumably, putative, ...litter scientific literature. If we...
06 August 2018 2,999 0 View
Reflection is thought unnecessary by the vast majority of humans today, both in science and out of it, both at RG debates and out of it. Can we continue to grow in intellectual stature without...
25 April 2018 7,192 3 View
Is the likelihood of a placebo response in migraine with aura patients much higher than in migraine without aura patients? Is there any evidence of a differential headache occurrence (severity and...
24 April 2018 3,293 0 View
Every now and then, there appears, as if on cue, a response that reeks of a supercilious hyper-cynical know-it-all knock-down-all damp squib nature or quality response in the columns of RG....
23 April 2018 6,684 4 View
Just like the immense anti-platelet value of aspirin was rejected when first presented to NEJM (Desforges, NEJM 329, 14, 1038-1039, 1993), the window of the difference between survival and death...
22 April 2018 7,721 0 View
Research manuscripts are handled on the basis of herd perception. The Editor-reviewer combine wheels herd perception into action the moment the submission is received. How can we leap-frog over...
20 April 2018 8,615 4 View
If a person can buy the alcohol at her/his own expense over decades, should we let the person also buy the liver transplant ? The social cost of alcohol consumption is enormous. The cost of...
18 April 2018 6,601 41 View
Interaction with humans is never a one-way street. The doctor is in command while interacting with patients, but educated intelligent patients are always evaluating the motives and competence of...
16 April 2018 4,348 14 View
A common refrain I get from my patients: The doctor did not even touch me but ordered a battery of tests. Is the touch-feel era of medicine over? Is it just an old-school lament? Is this demise to...
15 April 2018 3,481 10 View
Newton wondered why the apple did not go up and discovered the Universe of gravity. Notably he did this without complex experiments or trials or convoluted assertions, allowing the germ of the...
13 April 2018 9,479 2 View
A well-defined adaptive neuro-endocrine system keeps migraine at bay in the majority of the human population as well as offers periods of relative or absolute freedom from painful attacks in...
29 September 2017 9,941 4 View
Science is an oversimplification or a simple explanation for a seemingly complex observed phenomenon--this is a universal definition applicable to all branches of science. Science is not a simple...
30 August 2017 1,888 2 View
As an entirely independent researcher -- not receiving any research grant from any Organization in the World -- active in several fields in Medicine, including Cardiology, Neurology,...
29 August 2017 8,332 8 View
Nausea and vomiting are prominent headache-attack aborting features of migraine. Head-banging and other distressed behaviour including a marked restlessness characterize cluster headache while the...
28 August 2017 7,151 0 View
This is one of the toughest questions in migraine pathophysiology. I have described my own scintillating scotoma in the attached file. I am currently in the process of submitting an exhaustive...
24 August 2017 4,029 3 View
According to the biobehavioral model for migraine, intrisic (brain) noradrenergic system was considered the prime source of origin of migraine attacks (Prof. Welch). This put the autonomic nervous...
24 August 2017 4,067 2 View
Autonomic nervous system dysfunction is known in migraine since last 150 years. The ANS is a fundamentally adaptive or protective component of the central nervous system in nature and...
18 August 2017 5,045 3 View
I want only honest and INSTINCTIVE and TRUTHFUL replies without the respondents resorting to Google searches and/or PubMed or other several sources of information available on the Internet at the...
11 August 2017 9,173 8 View
Experiments with NTG suggest that it serves as a human-model for migraine. I invite comments to the validity of this assumption.
11 August 2017 2,988 0 View
The medical profession allows nutty trials, fooling the participants who are already over-stressed. This is nothing but a SHAME and a SCAM. I would not be surprised if there were to be a trial of...
01 January 1970 6,155 2 View
We think, therefore, we are. I start this thread, to celebrate and never end, our quest as a thinking species. "There is the churning and the boiling of the sea, and the foam on top of it and...
01 January 1970 6,074 11 View
Propranolol came into migraine research by pure accident or simplistic chance or retrogressive serendipity in 1967, leaving science and the migraine research community to struggle for its...
01 January 1970 8,986 3 View
Nicotine has a powerful neuroendocrine effect. Does nicotine cause or protect against migraine attacks? What are the mechanisms involved? Antimigraine action of nicotine: theoretical basis and...
01 January 1970 3,008 2 View
With example to stimulate research impetus rather than research grants, this thread will evaluate the basis of the spark that differentiates the plebeian from the sparkling wisdom that makes a...
01 January 1970 339 2 View
Australia announces plans to move embassy in Israel to West Jerusalem Australian news -- Yesterday Scott Morrison formally announced that Australia sees West Jerusalem as the capital of Israel....
01 January 1970 6,557 1 View
An Avoidable Medical Tragedy Murphy's law states that anything that can go wrong, WILL go wrong at some time. "Anything that can go wrong will go wrong." In some formulations, it is extended to...
01 January 1970 7,191 0 View
Starting as a serendipitous side effect in 1967, the mystery of the efficacy of some beta-blockers in the prevention of migraine has not dimmed. As migraine research carries on as a...
01 January 1970 8,658 2 View
The Netherlands Pharmacovigilance Center Lareb, in 2022, reported headache as the commonest adverse effect of intranasal corticosteroids (143 events out of 1258 individual) (Vol.:(0123456789)...
01 January 1970 5,335 4 View
Given the high prevalence of cigarette smoking worldwide, and its link to several forms of cancers / malignant diseases, this is vital to understand. The link between cigarette smoking and...
01 January 1970 5,541 3 View
Much can be learnt about the basis of primary headaches by focusing on cranial behaviour differences between cluster headache and migraine. Does cranial immobilization improve aberrant...
01 January 1970 9,614 4 View
EDS is variably common in migraine patients. Why and how? Quality of sleep, fatigue and daytime sleepiness in migraine—a controlled study S Seidel, T Hartl, M Weber, S Matterey, A Paul… - …, 2009...
01 January 1970 4,285 1 View
This most important issue has been swept-under-the-carpet of the massive and exponentially increasing data bank of migraine. Stress is a very common trigger for migraine, and, post-stress migraine...
01 January 1970 8,856 0 View
I am going to put all that I know about Nicotine and its clinical medical uses with its hazards at this ResearchGate site, to guide and warn users. Peer-review and editorial acceptance will take...
01 January 1970 3,384 3 View
Diabetes mellitus is the foremost known parameter of accelerated atherosclerosis, the major contributor of cardinal cardiac, neurological, and preipoheral neurovascular life-threatening...
01 January 1970 6,034 1 View
HALL OF SHAME By the 1920s, medical researchers had become heroes to many Americans (Lederer, 1995). By the 21 st Century, performers of Randomized Controlled Trials have become heroes in their...
01 January 1970 9,254 2 View
Can truth ever hurt? Must it hurt? Yes it can, if you have taken a contrary theoretical-philosophic-scientific position that you are willing to defend with your life and with your own take on the...
01 January 1970 2,856 3 View
I've Got Rhythm: Improving Memory Through Neurostimulation Steven Dubovsky, MD reviewing Reinhart RMG and Nguyen JA. Nat Neurosci 2019 Apr 8 Might a noninvasive resynchronization...
01 January 1970 5,331 4 View
Death of a patient -- a la Death of A Salesman, by American Playwright Arthur Miller, who famously married and divorced Marilyn Monroe as her second husband, a literary masterpiece in 1949 in...
01 January 1970 8,925 0 View
"Every research question has a different approach. True progress in science requires the ability to grapple with the immeasurable, the daring to view phenomenology differently, to give birth to...
01 January 1970 9,828 2 View
Keeping Murphy's Law, the KISS principle, and Popper's Logic, right, left, and center, respectively, as well as the all-encompassing muses of insight, innovation, intuition, imagination, and...
01 January 1970 7,799 6 View
To do research or not to do? Is it a Shakespearean twist of literature? Is it a game, the ropes of which can be learnt or taught, or is it an intrinsic gift, laced quite often than not with...
01 January 1970 9,331 0 View
Dissolution is the only truth for all who are born. Are we honest to ourselves and to our patients to a fault? Is attending to patients - human or animal -- a privilege or is it in current terms...
01 January 1970 8,559 0 View
01 January 1970 6,779 0 View
01 January 1970 3,146 0 View
I am a hardened hospital-based physician who has seen many patients pass on under my care over the last 42 years. Yet I could not stop my tears as I read Susan and Ani's piercing piece over...
01 January 1970 7,996 1 View
Much is recently being made about pre-natal gene editing in China by He. There were ethical concerns with the first human heart transplant at Groote Schuur Hospital in South Africa on December 3,...
01 January 1970 3,079 0 View
As the sole whistleblower in this field, I aim to dismantle the pretentious full, robust, generalizable, or predictable Popperian logical or Aristotelian synthesis-based gestaltic (ZEN, German...
01 January 1970 3,619 0 View
Research in migraine pathophysiology and therapy cannot progress until the deadwood that abounds is cleared. When such deadwood comes from the so-called migraine-research-establishment, the impact...
01 January 1970 3,941 0 View
Are we honest to ourselves and to our patients to a fault? Is attending to patients - human or animal -- a privilege or is it in current terms 'boring' and a 'drudge' or 'burn-out'. Most if not...
01 January 1970 5,476 0 View
Love is space and time measured by the heart -- Marcel Proust.
01 January 1970 8,088 0 View
Is the physiologic mechanism of vomiting associated with early pregnancy different from vomiting of migraine, motion sickness, cyclic vomiting, acute viral hepatitis with hepatocellular jaundice,...
01 January 1970 7,504 1 View
TicToc by BloombergVerified account @tictoc Dec 24More ICYMI: Here's how Kirstjen Nielsen responded when pressed about the number of people who have died in Homeland Security custody
01 January 1970 5,905 3 View
We should be able to appreciate and understand the lessons that come from experiments and measurements of clever and creative people, whether or not they follow the recipes established by...
01 January 1970 9,667 2 View
The Physician is dead. Long live the Physician. In recent decades, almost fifty years on, the clinical and research roles of the Physician (Internist-General Medicine) have progressively died...
01 January 1970 7,327 0 View
ResearchGate is an invaluable unique never-ending Global Medical Conference, wherein a constant meeting and clashing of scientific and philosophic minds, canonical beliefs, myths, assumptions,...
01 January 1970 6,085 2 View
By adding another dimension instantaneously, the UNEXPECTED, leapfrogs over decades and centuries of slogging at the bench as well as the bedside, and the in-vogue translation. Since migraine...
01 January 1970 1,434 0 View
To Fight Burnout, Organize How do we get to know we are winning?
01 January 1970 3,336 7 View
Meningeal contribution to migraine pain: a magnetic resonance angiography study Sabrina Khan Faisal Mohammad Amin Casper Emil Christensen Hashmat Ghanizada Samaira Younis Anne Christine Rye...
01 January 1970 1,397 0 View
Variability and trends in corticosteroid use by male United States participants with Duchenne muscular dystrophy in the Duchenne Registry Leslie Cowen1, Maria Mancini1, Ann Martin2, Ann Lucas2,3...
01 January 1970 2,473 0 View
