This is one of the toughest questions in migraine pathophysiology.

I have described my own scintillating scotoma in the attached file.

I am currently in the process of submitting an exhaustive review on CSD following the commissioning of the article by Editor-in-Chief of Journal of Neuroscience, having performed an exhaustive search of the scientific literature.

To be homonymous, the SS must be binocular and distributed in both right or both left halves of the visual fields of both eyes. I have not found any such case of SS distributed in a binocular fashion.

I have also described the basis for retinal origin of SS in the attached article. No in vivo proof can ever be obtained of mechanically-triggered SS at the level of the retina.

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