By adding another dimension instantaneously, the UNEXPECTED, leapfrogs over decades and centuries of slogging at the bench as well as the bedside, and the in-vogue translation.

Since migraine research has got lost completely in the woods of knowledge, and, is absolutely without a blueprint or an overarching matrix even while data keep piling on, the quote below as well as the pdf is immense value -- albeit only, to those with an open mind.

"Try to disassociate yourself from existing approaches and think about the shortest path to the answer,” says Gorbunova. “If you want to understand how to avoid cancer, study animals that don’t get cancer. If you want to study ageing, study animals that live a long time.”

Gorbunova and her colleagues cultured connective tissue cells from long-lived animal species. In a 2009 study they noted that a process in natural anticancer defences called contact inhibition, which prevents cells from dividing when they reach a certain density, occurs at a much lower cell density in naked mole rats.

The researchers found that a thick fluid seen in mole-rat cell cultures was hyaluronan — a substance with a wide range of functions in mammals, including in tissue formation, wound repair and joint lubrication — and that the mole rat’s hyaluronan molecules weigh five times more than those of human and mouse, and degrade more slowly. Both these differences slow the growth of precancerous cells and protect naked mole rats from cancer. "

“Keep your eyes open for the unexpected, and even if others think your idea is ridiculous, don’t give up,” says chronobiologist Bert van der Horst.

What can be more ridiculous in migraine research than bothering about the 4/5 of the human population that do not develop episodic migraine?? (Gupta 1997, 2009, 2009 (Adaptive Mechanisms in Migraine, Nova Science, New York. 2010, 2011, 2017, 2018, 2019). Three decades ago, a clarion wake-up call was published. As with several examples of originality, the silence it met with was deafening and appropriate.

New Delhi 2 April 2019

ORCID iD: 0000-0002-6770-5916