Newton wondered why the apple did not go up and discovered the Universe of gravity. Notably he did this without complex experiments or trials or convoluted assertions, allowing the germ of the shock to expand his mind.
This "Apple Shock" is essential to every field of endeavour and discovery.
Archimedes received the "Apple Shock" while bathing, a shock that divested him of his modesty.
A brilliant clarity of thought (not randomized controlled trials) follows the "Apple Shock" invariably.
Has the "Apple Shock" of migraine research come and gone unrecognized?
Possibly one of the impediments to migraine thinking is the IHS classification system, or to be more precise how the medical profession become slaves to it.
Paul Davies and Russell Lane wrote an excellent book called "Migraines" in which they explore the idea that all primary headaches have common factors and that they are triggered by the "migraine mechanism". They don't try to say that all headaches are the same, but lazy thinking means that people see for example 'episodic' and 'chronic' migraines as different entities even though the distinction is IHS convention (less or more than 15 days a month)!
Another "convention" is that patients universally cannot be relied upon to remember the frequency/severity of their headaches reliably. Of course, as a good clinician one has to look for supporting evidence by forensic questioning, but one result of a universally doubting position is that one refuses to consider evidence for new ideas that don't fit accepted paradigms!
The latest evidence of this is the way that Daith Ear Piercing for migraines has been totally ignored by the vast majority of the medical profession. It went viral on social media 3 years ago with many thousands of people having it done. There has been absolutely no medical research until my survey of 3000 people with migraines and a daith. The results on the face of it appear too good to be true, but if one analyses the subgroups there is a remarkable internal consistency, enough at least to take it seriously enough to do further research...
You can see the report on the the first of two surveys (an updated report will be published shortly to include the second) at:-