ROS are produced as a natural byproduct of normal metabolism and play an important role in cell signaling and homeostasis (Moris et al. 2017).
Since around the last decade, there has been a sustained interest in reactive oxygen species (ROS) in pathogenesis of migraine.
Can ROS accumulation explain the lateralizing headache as well as the scintillating scotoma and other characteristic features of migraine?
A study of oxidative stress in migraine with special reference to prophylactic therapy. Gyanesh M. Tripathi,Jayantee Kalita & Usha K. Misra.
Article A study of oxidative stress in migraine with special referen...
There is evidence of oxidative stress in migraine pathophysiology. Following treatment, oxidative stress declined following both pharmacological and rTMS.
Migraine Triggers, Oxidative Stress, and the Thyroid.
Borkum JM.
Headache. 2016 Apr;56(4):784-5. doi: 10.1111/head.12808. No abstract available.
Oxidative stress is not unique to migraine. E.G., cancer cells are permanently under oxidative stress. This is one of the reasons why they use the glycolytic pathway and upregulate the pentose phosphate pathway.
Any normal or malignant cell with high proliferation that remains in the OXPHOS metabolism is under heavy oxidative stress.
Cancer chemoradiotherapy produces oxidative stress also.
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