Studies concerned with the function of the autonomic nervous system in migraine suggested that a mild parasympathetic dysfunction may be present. In migraine patients, cerebral arteries are hypersensitive to nitric oxide which acts as an inducing factor for migraine attacks. As Nitric oxide synthase (enzyme responsible for nitric oxide synthesis) present in parasympathetic nerve endings in the region of cerebral arteries supports a crucial role for the association of parasympathetic nervous system in migraine. Several other factors have been also elucidated showing the association between the autonomic nervous system and the pathogenesis of migraine. Recently several population-based case-control studies have been conducted to confirm that whether migraine is associated with abnormal ANS function and findings of these studies suggested that ANS dysfunction either may be a risk factor for migraine headaches or be a consequence of frequent disabling attacks.

• The perspective involved needs a sea-change here.
• Everyone knows that stress is universal and everyone knows that stress is damaging.
• There is enormous amount of data already available in migraine research to implicate involvement of the ANS.
• So we know that the ANS and its 2 components are somehow involved.
• Rather than wasting more writing space, can we focus on the "how" of the matter?
• Can we please remain focused on the "physiological systems" involved by stress in migraine?
• The issue being forced here is the acknowledgement of a huge gap in comprehension that refuses to be filled up conventionally with additional data since 150 years of similar thinking and experimental or surveillance/observation evidences.
• The ability to file in a good-looking response with smooth words is not the objective here.
• Writing "words" is not equal to comprehension of disease "mechanisms".
• Read attached article fully -- it should take a good week to read it with the cross-references.
• Don't just take my word for it. Just read and understand the article -- the first main door to the comprehension of migraine and the ANS.
• Article was commissioned by the Chief Editor of Cephalgia in 1994--just because he had the courage to say that he did not know the "how".
• This hard acknowledgement is what you will precisely not do because there is a hindering perception of knowledge about migraine already extant in the PCB of your brain / mind circuits that does not allow you to start from the start.
• It is proven, even in basic medical science research, that where you start always affects where you end-up.
• NO, nitric oxide, is not the answer to my question. 
• No neuropeptide can help you here, otherwise the explosive advances in brain neuropeptide "knowledge" over the last two decades would have easily explained what you are trying to tell me and to the World. 
• Go ahead, and, exercise your choice.
•  In migraine patients, cerebral arteries are hypersensitive to nitric oxide -- please provide a reference for your statement.
• Nitric oxide synthase (enzyme responsible for nitric oxide synthesis) present in parasympathetic nerve endings in the region of cerebral arteries supports a crucial role for the association of parasympathetic nervous system in migraine -- please provide a reference for your statement.
• Please read about 'BIOLOGY of MIGRAINE', and begin your next interaction with me after writing down the meaning of this expression right at the top. 
• Do not, I repeat, do not try to trivialize the question or the level at which you are interacting with writings following your own Internet / Google searches of pseudo- or -partial compilations of knowledge.
• google searches do not amount to research systematic or to science itself. Otherwise the click-of-the-mouse would have already solved everything by everybody at lay as well as professional levels.

How to fund your own research?

Question

Jun 2017

• If you are a worried person regarding availability of research funds, you might have already been lost in the dreary desert of habit (Rabindranath Tagore) and dependency even before beginning your quest.
• There is an ocean waiting out there to be filled-up without research funds.
• Don't hold-up either the "quest" or the "ocean". 
• You cannot see that Ocean because you cannot feel/see the Foam (Rumi).