Currently i am researching about cancer stem cells micro-environment. I need some good papers(research) on this topic.Also therapeutic application targeting CSCs micro-environment.
Cancer stem cells (CSCs) are refractory to the microenvironmental stresses such as oxidative stress, inflammation, and hypoxia. CSCs have enhanced capacity to produce ROS scavenger characterized by GSH and TXN. Further, as Warburg effect goes, tumor cells tend to reply on aerobic glycolysis in parallel with glutaminolysis-induced TCA cycle in mitochondria.