malignant cell is formed according to the rule of :initiation,promotion then progression ,is the stem cell follows the same rule? OR/ it follows another theory ?
Few wrong mutations at the right sites of Normal stem cells that could not be detected and it goes into 4 cell divisions to get the mutation fixed....The results is CSC. 23 Pages in 3 lines.
Best,
Mannan
There is an extensive body of historic data behind the initiation, promotion, progression description of tumorigenesis, but even within the context of classical carcinogenesis experiments, there were compounds known as “complete carcinogens” that acted both as initiator and promoter, so that tumor development could occur without the application of another compound. So when addressing the question of whether the process of a stem cell being transformed to a cancer stem cell follows traditional oncogenic pathways, one needs to be aware that additional external factors in the microenvironment can also influence the tumorigenic pathway and complicate a straightforward answer. Serakinci et al., Oncogene, 2004 using bone marrow-derived skeletal stem cells, reported the first example of a human stem cell transduced with telomerase that spontaneously progressing to form tumors. This contrasted with prior studies using telomerase transduced primary human fibroblasts that indicated telomerase did not lead to neoplasia. Whether or not an innate quality of the stem cells enhanced the oncogenic process is difficult to say, given the rarity of such examples. However, stochastic acquisition of several oncogenic events over long-term continuous culture (three years) indicated that tumorigenesis remained dependent upon the accumulation of several additional contributing events. Bear in mind this was an experimental model. Nonetheless, in part answer to your question, it provides a precedent to show that in stem cells, tumorigenesis can follow a protracted path involving accumulation of some “typical” oncogenic aberrations. In vivo, the microenvironment is more complex, yet evidence that crypt stem cells may be the predominant cells of origin for intestinal cancer (Barker et al., 2009) suggested that in some tissues there may be a predisposition for tumorigenesis in stem cells.
Hi Ibrahim,
Conversion of normal/stem cell to cancer stem cell is a complex process. You can see our recent publication-
https://www.ncbi.nlm.nih.gov/pubmed/25659759
Think it might help you
Cheers
Farhad
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