Cancer stem cells are the precursor of spreading cancer throughout the body. I need some article (research & review) where hormonal effect over cancer stem cells for food consumption illustrates.
Thanks in advance
When the ovarian hormones like progesterone levels elevated in tumor micro environment, it may develop a link between CSC and normal epithelial cells which may triggers the CSC population and eventually spread the disease.
progesterone may help in the maintenance of stem cell niche, there by giving an opportunity for cancer cell transformation.
IGF and IGFR1 seem having a connection to your question, that I don't catch if it goes far away as being connected to the hard problem of Tumor cachexia, where several therapies were tested, from drugs that increase appetite, as those once used for children, mostly not for having the kids eating well, but for pacifying their parents' anxiety about how the kid will grow up.
Cannabis, having active components that do induce hipoglycemia, thus increasing appetite, was used for the purpose, as Progestins were, but these from an anabolic/ perhaps an anti-inflammatory effect.
New drugs were proposed recently for cancer cachexia, and I always doubt if the Rheumatologists' drug Tocilizumab, that acts against IL-6, a putative effector of cancer cachexia, may have any positive action on it.
The Leptin/Ghrelin balance and druggation have been considered for this too.
Anyway, I'm a clinician, not a bench person. Thanks
- Badges
- Science topic
- Similar topics
- Medicine
- Oncology
- Cancer Research
- Cancer Biology
- Cancer Cells
- Cancer Stem Cells