does someone know if it exists an experiment where tumoral and non tumoral cells have been cultured together? if yes, please link me the literature! thank you
If not too late ... some (more than) interesting articles from both experimental and theoretical point of views ...
Best regards,
Robert
PS: Napoli is a beautiful city!
Probably you should give more informations about your Topic, because there are hundreds of paper out, which co-cultured cancer cells with normal tissue. Do you address a Special issue?
My question is about general: I was wodering what happens to normal cells when they are in contact with tumor cells: e.g. if one population is predominant on the other (I mean e.g. tumor cells use all the nutrients and grow whereas normal cells die), or if normal cells become tumor cells too...I don't know if a special issue exist, if yes, please post it, thank you!
There are many areas in which the interactions between tumor cells and host cells are studied. Many study the effects on the immune system (tumor-associated myeloid cells)) and vessel formation . See for instance this review
Blomsnka et al Shaping of the tumor microenvironment: Stromal cells and vessels. Semin Cancer Biol 2015 Mar 18
Thank you Jonas for having linked this interesting review, however it is focused on the interactions between tumors and its natural (in vivo) cell microenvironment. Instead, I am looking for experiments in vitro with cultures of two cell populations, one of which is a tumor.
Most normal cells cannot be cultured at all. Most cell lines are either directly from a cancer (HeLa etc) or have been "transformed" in vitro to become able to grow and divide in culture. There are thousands of types of cancer cell lines, and thousands of types of normal cells, so it would not be correct to compare what happens when say HeLa cancer cells are co-cultured with a particular type of normal cells.
this is a right observation, brian. in fact it is supposed that tumor cells have some characteristic that make them more prone to be cultured and to proliferate in comparison with non tumor cells. for the moment I found something here, about interactions with fibroblasts and prostate cancer http://www.ncbi.nlm.nih.gov/pubmed/22593435
My colleagues have published on a co-culture system where you can add different cell lines to it. We used it for prostate cancer epithelial cells and mesenchymal cells.
Article Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential
If not too late ... some (more than) interesting articles from both experimental and theoretical point of views ...
Best regards,
Robert
PS: Napoli is a beautiful city!
Thank you Robert for all these reports. It is not late, I am still much interested in this topic
ps. yes Naples and its environments are amazing. Thank you
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