Why do Anticancer drugs kill a constant fraction of cells (Log-kill Hypothesis) rather than a constant number of cells ?
Anticancer drugs follows log-kill Hypothesis I.e kills constant fraction of cells because of the specificity of the chemotherapy drugs to the cell cycle of the cancer. Example is use of Cytarabine in treatment of leukemia.
I am reading papers on batteries and although mostly people have reported ionic conductivity in Scm-1 but some have reported DC conductivity as well I and am confused as to what that is. Any help...
21 February 2021 9,207 6 View
There is too much discrepency among the textbooks of vertebrate embryology. There are two interpretations of the term "Prechordal plate" in different books: It is the cranial most part of the...
24 November 2020 8,537 1 View
Hi, I want to know how to find the %crystallinity from PXRD peaks. I have a highly amorphous compound where I get a broad peak. For your reference my PXRD looks same as in the following picture.
26 September 2020 6,191 5 View
Hi. I am doing simulation of compression testing of a spring.My experimental and simulation results are same in the linear region. I have tried the simulation with all types of contact behavior...
10 September 2020 1,746 3 View
As we know that the Deep Learning frameworks, consumed in most business operations, are growing rapidly. I have surveyed that Python, Java and C++ are the most widely used languages for Deep...
29 June 2020 1,144 3 View
I had a few questions regarding Convalescent Plasma Therapy Why can't we use whole blood rather than convalescent plasma only? or Plasma + WBC (Adoptive cell transfer). This way we will transfer...
10 June 2020 2,361 9 View
Almost all the microbiology textbooks and relevant research articles mention that Hepatitis B core antigen is not released into the blood of the host. It rather interacts with other core antigen...
14 April 2020 5,420 6 View
I know both can detect presence of virus but what is the exact difference between qPCR and qualitative PCR ? How and when is one preffered over the other?
15 March 2020 9,814 4 View
Companies like Moderna are working on mRNA based vaccine as they can trigger both cell mediated as well humoral arm of immunity. But why traditional protein based vaccines can't trigger sufficient...
29 February 2020 9,023 3 View
I want to know which one will be performed through acid digested and then extraction. or only after gringing extraction can done only.
22 January 2020 3,949 4 View
02 March 2021 3,060 3 View
Hello all, In SPSS I am going to code 2 open-ended questions. I have already read all the answers and I made a list of the most important categories to which I can code the answers. This question...
02 March 2021 1,757 4 View
I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...
02 March 2021 9,945 3 View
Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...
01 March 2021 3,867 3 View
Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?
01 March 2021 8,087 3 View
We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...
01 March 2021 3,355 3 View
I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...
01 March 2021 3,703 3 View
I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....
01 March 2021 3,607 3 View
Hi, I am running a size exclusion chromatography experiment with a buffer containing Potassium Acetate as a salt. I analyse these fractions through SDS-PAGE. After boiling my SEC fractions in...
01 March 2021 2,622 3 View
Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...
01 March 2021 8,169 2 View