I’ve been looking at antibody like Ig’s, receptors that bind to transferrin, insulin, and LDL:LDLR but their main problem, excluding some immunoglobulins, is that they’re competitive agonists.
For Tf, there’s melanotransferrin, but this will include having to PEGylate a proteoliposome I’m planning to create to express the melanotransferrin.
Are there any other ligands I could use to reversibly bind to these receptors that shuttle it across the BBB and then to glioblastomas?
I also have two types of proteins that target cancer or apoptotic cells embedded in the proteoliposome I’m creating too.
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