We are going to use DMH colon cancer model in our lab (e.g. 30 mg/kg i.p. once a week for 10-20 weeks, Wistars) to assess the influence of some nutritional factors on colon carcinogenesis.
I didn't find any safety tips for this model so far. Are there any data about the amount of unchanged DMH or some of its toxic/carcinogenic metabolites being excreted by animals during the modeling? Should there be some additional safety measures for cage bedding disposal and for staff who's cleaning the cages?
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