In the study by Neuwinger et al. (2019) on underfilling of blood collection tubes, several key observations were made regarding the differences in lactate dehydrogenase (LD) activity between completely filled and underfilled blood collection tubes. The study demonstrated that insufficient filling of blood collection tubes, whether serum (SE) or heparin plasma (HP), resulted in falsely elevated LD activity measurements.
Yes. Alongside lactate dehydrogenase (LD), underfilling of vacuum blood collection tubes can impact other biochemical markers and enzymes. For instance, potassium (K) concentration in the blood sample may slightly elevate due to underfilling. Additionally, the hemolysis index, which measures the extent of red blood cell breakdown, can significantly increase.
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