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Questions related to Cancer Research
We are conducting a study on docking of different ligands against different cancer targets. kindly suggest best breast cancer target proteins for docking studies.
10 July 2017 7,423 4 View
I want to see mutations and allele frequencies in oncogenes in a prostate cancer, but I need a tool that could provide information in free access accounts. I tried oncomine but it has some...
10 July 2017 9,330 3 View
I would like to identify my injected human CD14 monocytes histologically in mouse hearts, however, the antibodies we tried (even the ones specifically advertized for xenograft models)...
03 July 2017 8,792 2 View
What is Positive control Ehrlich ascites tumor? Could be Cisplatin?
03 July 2017 9,780 1 View
co-expression about protein
02 July 2017 7,007 2 View
Hello everyone, I have done DNA sequencing on mouse samples after treatment with drug.. i wanted to see if there was any mutations caused by that drug.. I have found some mutations but...
30 June 2017 5,100 3 View
Hello, I was wondering if anyone knew of methods to increase intracellular calcium levels? I am currently working with cardiac glycosides which are know to increase intracellular calcium levels...
26 June 2017 6,018 3 View
Mutant kras leads to constitutive activation of downstream factors, what if we directly delete Kras in the tumor tissue? Will there be tumor regression? Also, people don't target KRAS is because...
23 June 2017 4,607 4 View
Hi, I am new to the field of immunology. I am trying to understand the different sources of cancer neoantigens and they can be utilized for immunotherapies. In one of the books, I read that...
18 June 2017 9,110 3 View
In cancerous some cells of the organ are normal and some are abnormal, so if we can detect these abnormal cells depending on the genotype, then we can find a way to eradicate specifically the...
15 June 2017 3,834 5 View
My drug treatment reduces mutated P53 and Plk1 protein expressions in MDA-MB-231 cells model, I know mutated P53 acts as a proto-oncogene. But I can not find a solid relation between P53 and...
13 June 2017 9,069 2 View
I am working with CTCs separation and analysis. I have not found any paper on CTCs subclasses classification and the detection method using molecular tools. Where can I get knowledge about CTC...
11 June 2017 1,982 2 View
ROS, I know at low levels promote tumor growth and moderate levels active HIF1A which result in increase in glucose uptake. But at high levels, lead to cell death via DNA damage or apoptosis. So...
07 June 2017 1,449 2 View
These two unfortunate patients are among those who develop melanoma from pre-existing nevus with metastasis in the liver.
04 June 2017 9,607 3 View
I am trying to induce EMT in breast cancer cell lines using LPS (10 ug /mL) as per other literature suggestions (MCF-7 and MDA-MB-231) but I am not able to get significant reduction in E-cad in...
02 June 2017 3,433 12 View
What is the different of B16 & B16-F10 melanoma cells？ And which of them can be use for subcutaneous tumor models in C57BL/6J mice？
01 June 2017 4,946 4 View
Hi! I am trying to find a good immunocompetent mouse model to study triple negative breast cancer (TNBC). The 4T1-BALB/c model is perhaps not ideal for studies on immunosuppression and as 4T1 is...
29 May 2017 6,230 4 View
Hi guys!Next week I have my first 'serious' interview for a postdoc position job that REALLY interests me. It would be done on Skype, I was asked to prepare 20-minutes powerpoint presentation on...
21 May 2017 3,991 17 View
In orthotopic lung mouse model, Lets suppose primary tumor is at lung A and after 4 weeks we observe metastasis at lung B, how we can calculate the rate of metastasis
18 May 2017 1,044 3 View
In breast, Estrogen is synthesized from androgens by aromatase enzyme. In breast cancer cell culture, where the adrenal androgenic precursors are not present, what could be the source of estrogen?...
10 May 2017 2,388 6 View
Hi, I am looking for the aberrantly expressed S-nitrosylation proteins in glioblastoma multiforme (GBM). I want to examine the TCGA dataset and examine the enzymes responsible for this...
07 May 2017 3,574 3 View
I've been tasked with figuring out if certain murine cancer cell lines express specific cancer antigens we would like to target. For instance, does the 4T1 breast cancer tumor model express WT-1?...
01 May 2017 5,648 1 View
breast cancer induced chemically / cell line - non nud mice - metastatic bone cancer -
27 April 2017 6,430 5 View
Does anyone have a protocol for ellman's regent test. I was looking at some protocols and one article mentioned using Cysteine Hydrochloride Monohydrate as a standard control. the article also...
26 April 2017 435 3 View