ROS, I know at low levels promote tumor growth and moderate levels active HIF1A which result in increase in glucose uptake. But at high levels, lead to cell death via DNA damage or apoptosis. So what are the ranges of ROS levels in tumor cells?
Gregory Barshtein
I hope that following review will be helpful.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207279/
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Zaheenul Islam Siddiqui
in tumors, not all cells will have the same levels of ROS, but there will be different populations of cells having different ROS levels in the same tumor. this is to exploit all the nefarious possibilities in which ROS can contribute to cancer development and progression, some of which u have already mentioned.
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