Mutant kras leads to constitutive activation of downstream factors, what if we directly delete Kras in the tumor tissue? Will there be tumor regression? Also, people don't target KRAS is because that KRAS is important in normal tissue? So the goal is to find genes that are important in KRAS signaling but not important in normal tissue?
https://www.ncbi.nlm.nih.gov/pubmed/28643779
https://www.ncbi.nlm.nih.gov/pubmed/25323927
There you can find an interesting view about it.
Hi Suipwksiow,
Yes, it would be great to "directly delete" mutant KRAS in tumors. But how would you do that? Not in a dish but in a patient?
Drugging it turns out to be quite tricky, as you can see in the links above.
Article Molecular genetics and cellular events of K-Ras-driven tumorigenesis
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