Hello everyone,
I have done DNA sequencing on mouse samples after treatment with drug.. i wanted to see if there was any mutations caused by that drug.. I have found some mutations but unfortunately they do not have human homologues!
My question is, if they don't have human homologues does that mean they are not important!? is it possible that they only cause mutations in mouse yet not to humans?
forgive me for my basic questions but this is my first time doing sequencing analysis.
I appreciate your answers
thank you
Delilah: A lack of human homologues may suggest the importance of a gene. It's like ly that your mouse gene may not have an identifiable protein product or function. I'd reproduce the result and try to understand more of this gene before making conclusion(s).
@ke-wei zhao thank you for your input.. i was confused because i noticed the same mutation in that gene in both the control and the treated samples.. even though we did genotyping before and that gene was not there
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