We are trying to analyse the role of memory B cells in in patients with Visceral leishmaniasis by flow cytometry using the marker CD27 and IgD . We are getting increased frequency of memory b cells after post treatmet in VL . So can anyone suggest the possible role of memory cells in protozoan diseases.
Immunity to Leishmania has long been known to depend on the development of type I immune responses characterized by initial production of Interleukin-12(IL-12) by antigen-presenting cells (APCs) that induce Interferon-γ(IFN-γ)-secreting Th1 T cells
there is an old review which might answer some of your questions: Article The immunopathology of experimental visceral leishmaniasis
Dear Shilpa Sengupta, very interesting study, wish you all success, please follow the links below for farther informations.. Good luck
What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445636/
Regulation of immunity during visceral Leishmania infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774109/
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