From practical point of view (keeping aside research aspirations), what are the basic requirements of a candidate specimen for being a good system for magnetic hyperthermia applications? As per my understanding we need the followings.
1) System must be stable overa a large period of time. (I mean no settlement).
2) System must be capable of attaining hyperthermia temperature window (43-45 deg-cels).
3) System must be bio-compatible.
Any other most essential properties are required? Kindly comment.
Advanced thank you.
There are two possibilities to heat magnetic particles by subjecting them to AC magnetic field (1) FM particles and (2) Superparamagnetic particles. The amount of heat generated in case of former can be calculated by hysteresis loop while for the later Rosensweig has developed a model based on Debye theory for dielectric dispersion in polar fluids. It is shown that the amount of heat generated depends on square of the applied field and imaginary part of complex magnetic susceptibility which in turn depends on driving frequency of the field. So, one has to calculate the amount of heat generated at a give target in the body. For safety it is necessary to use types of magnetic particles that has a large pyromagnetic coefficient and Curie temperature around 43 degree Celsius.
Hi,
Atkinson et al concluded that exposure to fields where the product Ho x f does not exceed 4.85 x 10-8 Am-¹ s-¹ is safe and tolerable so the particle should respond to a frequency and field strength that stay within this limit - typically somewhere between 100 kHz to 1 MHz and 1-15 kA/m.
for more information please see the link below
http://www.nanotherics.com/magneticnanoparticleheating.htm
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