Increasing numbers of naïve cells in immunogenic (in vitro) experiments - how is it possible that there are more naïve PBMCs after antigen exposure than before? Any additional papers on this topic will be greatly appreciated!
Thank you in advance for your help in interpreting this phenomenon!
Hello Joanna Baran
Naïve lymphocytes receive three types of signals:
1) an antigen signal through the T cell receptor (TCR) or B cell receptor (BCR),
2) a co-stimulatory signal, and
3) a cytokine signal.
If a naïve cell receives all three signals, it differentiates into an effector cell. Naïve B cells differentiate into plasma cells that secret antibodies, and T cells differentiate into various effector T cell subsets, such as CD8+ T cells (killer cells) or CD4+ T cells (helper cells).
If a naïve cell only receives the first signal i.e., the TCR or BCR recognizes an antigen but does not receive a co-stimulatory or cytokine signal, the cells are rendered anergic.
Best.
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