I am an engineer trying to understand breast cancer stem cells. I understand breast cancer can be classified according to its molecular signatures e.g. HER2+ or TNBC. Do these classifications apply to breast cancer stem cells? Are there stem cells that belong to TNBC specifically or do we talk about stem cells more generally across the various kinds of breast cancers.
Thanks.
Human breast cancer includes a highly diverse set of diseases and is classified in to at least 6 distinct clinically-relevant molecular subgroups - luminal A, luminal B, HER2+/ER-, basal-like, normal breast-like, and the most recently recognized claudin-low. It is clear that at the molecular level, each breast cancer subtype displays distinct gene expression profiles, and exhibits significant differences in response to therapy and patient outcome
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