Is there known genetic predisposition to upslantig palpberal fissure and what about its association with spina bifida ?

06 July 2016 9,638 3 View

Is there any article show presence and role of calcitonin gene related peptide in Langerhans cells?

It was shown that Langerhans in esophagus contain calcitonin gene related peptide, and that number of these cells and their immunoreactivity to calcitonin gene related peptide increase in reflux...

01 February 2016 718 1 View

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11 December 2015 2,619 3 View

Do metastatic lines reqiure MET (mesenchymal to epithelial transition) when inject intravenously in for colonisation?

08 September 2015 533 5 View

Is it mandatory to do functional repopulation assays to identify cancer stem cell?

If you want to show inhibitory effect of some drugs on cancer stem cells , is it sufficient to isolate cancer stem cell from clinical specimen depend on specific cell marker that previously test...

08 September 2015 7,068 3 View

Do metastatic cells re-metastasize ?

06 July 2015 9,598 12 View

How can we link skeletal muscle specification during embryology and rarity of skeletal muscle metastases ?

31 December 2014 9,159 1 View

Is there reciprocal interaction between primary tumor and premetastatic niche that is mediated by extracellular vesicles(exosomes and microvesicles) ?

there are studies show reciprocal interaction between cancer cell and stroma mediated by extracellular vesicles ( cancer cell release microvesicles affect stromal cells which in turn release...

11 December 2014 7,310 5 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

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02 March 2021 3,060 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View