there are studies show reciprocal interaction between cancer cell and stroma mediated by extracellular vesicles ( cancer cell release microvesicles affect stromal cells which in turn release microvesicles affect cancer cell) at primary tumor enviroment, in addition cancer cell release extracellular vesicles play a role in pre-metastatic niche formation .
but is there reciprocal interaction between primary tumor and pre-metastaticniche mediated by these vesicles ( i mean do cells in premetastatic niche also release extracellular vesicles affect primary tumor ?)
There is a possibility that circulating exosomes derived from tumor cells in the primary site affect the pre-metastatic niche, thereby induce the neo-angiogenesis and recruitment of fibroblasts in CXCL12/CXCR4 axis-dependent manner.
The short answer is YES. Tumor-derived exosomes contribute to an inflammatory microenvironment that promotes tumor metastasis through multiple mechanisms. Further, the microenvironment is impacted by exosomes derived from stromal cells. Therefore, depending upon the system under study and research focus, one can demonstrate communication through exosomes/microvesicles between the primary tumor cells other cell types surrounding the tumor.
The short answer is Yes, there were several publications demonstrating that patient derived exosomes (melanoma and ovarian) increase the tumor load upon priming with the exosomes before tumor cell injection in mice.
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