some miRNAs decrease proliferation of cancer cells. in this case, does the use of thearpuetic agnets which upregulate these miRNA can help treat cancer? and what is the difference between regulation and gene expression of miRNA ?.
To be honest, just a proliferation control is not preferred in cancer therapy unless it helps to prolong patient survival. If I were you, I would prefer something more pressing in need..!!
Ok. let me add more details. In the context of cancer cells, miRNAs regulating cell death would be preferred. In the context of immune cells it can be a cytokine regulatory miRNA or maturation or activation regulating miRNA would be preferred for immunotherapy. As you said, differentiation regulatory miRNA would be beneficial in a sub-set of cancers such as PML where differentiation is needed for cell death (ATRA story goes here).
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