I have silly question about why putting HCl salts with the drug.
For example, I have doxorubicin and it says DOX with hcl salt.
wel, I heard that this thing makes DOX better solubility. however, my question is that isn't DOX already soluble in water ?
and if not, why?
and also, why hcl salt???
so let me organized my questions.
1. if DOX is not soluble in water, why?
( I don't see why though, there is carbonyl groups and amine. and amine and carbonyl groups are very soluble in water right? if not why? )
2. why hcl ? the most dangerous thing with the drug? and why they are SALT ??? this is just so weird ...
3. does it effect the pH ?
4. what make them more soluble after putting most dangerous salt ?
I have spent hours and never be able to find good answer for it.
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