EC 1.14.14.1 is the accession number of CYP1B1 enzyme. I know that the first number '1' refers to the major class of the enzyme catalysis reaction, I want to understand the meaning of the rest of the numbers in this enzyme accession number.
A 4 digit Enzyme Commission (E.C) number is assigned to each enzyme representing the class (1st digit), sub-class (2nd digit), sub-sub class (3rd digit) and the individual enzyme (4th digit).
Thanks Sarmistha Sarkar, that what i understand, but how can i know to what do the numbers in 14.14.1 refer in exact manner?
Dear Fred Hoogendoorn
, thank you for your informative answer.best regards
The answer to your question has been answered perfectly but it may interest you learn why this clunky system was introduced. From the knowledge of enzyme catalysis it was recognised that the reactions ctalysed could be identifiied s belonging to certain groups e.g. oxidoreductases, transferases, hydrolases etc.and each group was given a number (the first digit in the EC code. Other digits are added to denote the chemical group acted upon, coenzymes and a catalogue nnumber n a list of enzymes that all fall into a particular category. For example, Alkaline phosphatase is 3.1.3.1. The older literaure could be confusing because not all authors used the same name for a given enzyme. Editors of biochemical journals used to insist that the EC number was always quoted in submitted publications dealing enzyme work. This acted as an absolute identifier. The requirement seems to have lapsed somewhat but Suzanne has obviously come across the EC system.
Peter
Suzanne Jubair Thank you for asking the question. I also learned a lot from the answers.
The first number indicates the major class or main class of the enzyme (Here, 1 refers the main class as Oxidoreductase), the second digit (14) indicates the sub class of the enzyme (Here 14 refers - ), the 3rd digit (14) indicates sub subclass (here 14 refers- a kind of a monooxygenase ) and the last digit - fourth digit (1) refers the serial number of the enzyme or the order of the substrate or the particular substrate (Here, 1 refers the substrates -unspecific- Unspecific monooxygenase )
The relevant source is the IUBMB nomenclature homepage (http://www.sbcs.qmul.ac.uk/iubmb/). The EC numbers are used for information services on the internet, for example BRENDA (http://www.brenda-enzymes.info/), which is the first stop when you have questions about an enzyme.
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