I want to choose a resarch topic regarding enzyme inhibition. So I did my research and found out most of the diseases that originate from enzymes were actually caused by the "deficiency" of enzymes, not the "activity". For the sake of my reaserch, I want to find troublesome enzymes (such as ACHE) that their high activity causes problems in body or metabolism. What are the examples of it?
Enzymes with problematic high activity include acetylcholinesterase, monoamine oxidase, xanthine oxidase, matrix metalloproteinases, cyclooxygenase-2, 5-alpha reductase, aromatase, and angiotensin-converting enzyme. These are associated with various conditions including neurological issues, depression, gout, cancer, inflammation, prostatic hyperplasia, and hypertension.
It's a long list. You could include the various tyrosine and serine/threonine kinases associated with cancers and some autoimmune diseases. Inhibitors of clotting factors thrombin and factor Xa are used to prevent strokes and heart attacks. HMGCoA reductase and PCSK9 inhibitors are used to lower LDL cholesterol. Work is being done to develop inhibitors of the serine proteases involved in complement activation to treat a variety of conditions.
You could also include the many anti-infectives targeting enzymes in bacteria, fungi and viruses. The diseases don't "originate from the enzymes," but they are treated by inhibiting enzymes in the infectious agent.
هناك العديد من الانزيمات التي يسبب ارتفاعها اوانخفاضها الديد من الامراض مثل انزيم الفوسفاتيز القاعدي الذي له علاقة بامراض الكبد والعظام وانزيمات وكذلك انزيمات الكرياتين والكرياتننين في العضلات
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