I just wanna adjust one point here:
The nomenclature 5'/3' is used, if no arm is favored and both arms seem to be functional. The asterisk is used, if one arm seems to be favored and the one with the asterisk is the non-functional arm. Nevertheless, the mature microRNAs with an asterisk can absolutely be functional. There are publications out there showing arm-switching microRNAs. In different tissued, or developmental stages, different arms are loaded to the RISC complex.
To sum it up: I like more the 5'/3' nomenclature, since it does not hold any information which might be wrong.
If I remember my miRNAs correctly, it indicates the strand from which the miRNA is transcribed. Someone correct me if I'm wrong here.
5p means the microRNA is from the 5 prime arm of the hairpin and 3p means 3 prime end. Sometimes the 3p arm is also labeled with with an asterisk. i.e. 140-3p = miR-140*
Many believes the 5 prime mircorRNA is the dominant strand which gets incorporated into the RISC and the 3 prime (or miR-140*) is the minor strand with little function...... however there are evidence out there suggesting the 3 prime microRNA also has a function.
I just wanna adjust one point here:
The nomenclature 5'/3' is used, if no arm is favored and both arms seem to be functional. The asterisk is used, if one arm seems to be favored and the one with the asterisk is the non-functional arm. Nevertheless, the mature microRNAs with an asterisk can absolutely be functional. There are publications out there showing arm-switching microRNAs. In different tissued, or developmental stages, different arms are loaded to the RISC complex.
To sum it up: I like more the 5'/3' nomenclature, since it does not hold any information which might be wrong.
Nice, now if we found an article showing that miRNA is named as miR-20, what dose this means (5p or 3 p) if we want to rely on this paper
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