I aim to be as skeptical as possible regarding whether a pair of orthologous genes results in the same phenotype in their different but related bacterial organisms under similar environmental conditions.
"Methodology ..... To determine whether type IV pili play a role in bacterial host-cell adhesion, we measured the ability of wild type A. nosocomialis M2 and mutants with altered type IV pili biogenesis phenotypes to bind to immortalized lung (A549) and nasopharyngeal (Detroit 562) epithelial cells in vitro."
"Introduction ..... We demonstrate that Acinetobacter type IV pili promote host-cell adhesion in a manner independent of C-terminal glycosylation."
"Abstract ..... examine the consequences of this heterogeneity for protein folding and assembly as well as host-cell adhesion by Acinetobacter."
Article Structural Diversity in the Type IV Pili of Multidrug-resist...
Maybe there is something in the details that makes a working interpolation possible.
The authors extrapolated the phenotype across the whole genus due to genetic and physiological similarities, historical precedent, resource limitations, initial supporting evidence, and to generate hypotheses for further research
Niamat Ullah
"The genetic determinant(s) that are causative of a particular phenotype can also be of a different nature than a gene, and can include particular sequence variants, or alterations of regulatory elements in intergenic regions."
Article From genotype to phenotype: computational approaches for inf...
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