Detection of NF-kB (p65) in the serum is interesting and not surprising. Numerous proteins are are detected in serum. Therefore, additional information could help- is the serum from a healthy individual? If not, any known inflammatory diseases? The presence of p65 in the serum could indicate cell death-associated with pyroptosis in cells and tissues, which is accompanied by inflammation.
Detection of NF-kB (p65) in the serum is interesting and not surprising. Numerous proteins are are detected in serum. Therefore, additional information could help- is the serum from a healthy individual? If not, any known inflammatory diseases? The presence of p65 in the serum could indicate cell death-associated with pyroptosis in cells and tissues, which is accompanied by inflammation.
It's ture. It's indicate the cell death. A connection is not linear.
Clearly interesting to measure; just to remember that NFkB is a complex, and maybe would be more informative to detect other proteins along with p65, and try to correlate with specific pathologies.
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