Divaker Choubey

7 Questions 511 Answers 0 Followers

Questions related from Divaker Choubey

What is known about the role of p53 pathway in the development of colorectal cancer (CRC) using mouse models?

In chemical-induced colitis-associated cancer mouse models, treatment of mice with azoxymethane (AOM; a mutagen and carcinogenic compound) and dextran sodium sulphate (DSS) in colon epithelial...

21 April 2016 6,108 5 View

How convincing is the evidence that B cells can assemble an inflammasome upon sensing a danger signal?

Both myeloid (e.g., macrophages and monocytes, and DCs) and non myeloid cells (e.g., keratinocytes and epithelial cells) are shown to sense certain "danger" signals and activate inflammasome, thus...

20 April 2015 519 3 View

What do we know about the role of inflammasomes in the development of inflammation-associated human cancers?

Studies in certain mouse models have indicated that activation of inflammasomes protects against the development of cancers. However, the role of inflammasomes remains unclear in the development...

20 February 2015 4,336 5 View

Does anyone know a commercial source of adenoviral expression vector to express the interferon-alpha?

We would like to over express the IFN-alpha gene in primary cells after adenoviral delivery.

22 September 2014 3,731 3 View

Remdesivir: what do we know?

There is growing optimism about Remdesivir, a repurposed drug (tried for hepatitis C and Ebola treatment) to treat COVID-19 patients. The drug is structurally similar to a component of the...

01 January 1970 5,072 3 View

COVID-19 infection and hydroxychloroquine treatment: what do we know?

Hydroxychloroquine (HCQ) is an antimalarial drug. The drug is used to prevent and treat acute attacks of malaria. Additionally, HCQ is used to treat systemic lupus erythematosus (SLE) patients...

01 January 1970 9,931 13 View

COVID-19 virus infection and associated potential pathologies: what do we know?

Based on the information widely shared in the news and social media, the COVID-19 virus infection impairs the ability of the infected individuals to breath (and oxygenate the blood). This...

01 January 1970 1,680 3 View