Hi, everyone, the paper below reported that the IMT of common carotid artery had a poor correlation with pressure-strain elastic modulus at lower thickness value (CIMT0.88mm, r=0.62, p
Yes it is rightly mentioned. Stiffness (ability to dilate) decreases with increased thickness of blood vessels (IMT). But there is non linear corellation between thickness and stiffness as there are many mechansim that contribute towards vessel stiffness. and one mechanism contributing is IMT.
Hello,
in Graz at the Technical University is a group in biomechanics who have done a lot of work in carotid arteries, and one of them is Prof. Jinhua Tong, who is now in Shanghai. Some examples of their work:
Sommer G, Holzapfel GA.3D constitutive modeling of the biaxial mechanical response of intact and layer-dissected humancarotid arteries.J Mech Behav Biomed Mater. 2012 Jan;5(1):116-28. doi: 10.1016/j.jmbbm.2011.08.013. Epub 2011 Aug 31
Tong J, Sommer G, Regitnig P, Holzapfel GA. Dissection properties and mechanical strength of tissue components in human carotid bifurcations.Ann Biomed Eng. 2011 Jun;39(6):1703-19. doi: 10.1007/s10439-011-0264-y. Epub 2011 Feb 9.
I hope You can find information on Your problem, or You could contact those authors directly. Yours Tina
Arteriosclerosis is a multiple tissue type lesion the mechanical properties of which vary with the components of the lesion that are present during its development. These lesions evolve different structures, plaque, fibrosis, thrombosis, calcification, and so forth, at different stages of the lesions' maturity, e.g., see
"A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis"
The increase of thickness is mostly due to a increase of collagen (fibrosis) and calcium plaque. this changes the ration between more elastic components such as elastin compared to less elastic ones (collagen and calcium plaques).
Interstingly, a non-atherosclerotic intimal thichenig not associated to arterial stiffning could be observed. E.g., we have ongoing not published data about Fabry's disease and Takajasu's disease. Moreover, IMT and AS determination is not easy to perform. We now use new "quality" methods (see my attached review). Finally, I suggest you to read the old but intriguing above work (Hyperviscosity could be a protective factor?)
Glagov, S., et al. "Mechanical functional role of non-atherosclerotic intimal thickening." Frontiers of medical and biological engineering: the international journal of the Japan Society of Medical Electronics and Biological Engineering 5.1 (1992): 37-43.
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