I am working on the measurement of radial forces exerted by self-expandable cardiovascular stents. I need to know how much force can damage the intima of arterial walls? Please refer me to a research or article with the values.
Sina,
I don't think that you'll find a one-size-fits-all relationship.
Plaques come in all shapes and sizes, and they modulate the strength of underlying tissues of the arterial wall.
Plenty of researchers have attempted FEA modelling:
Article Computational Evaluation of Artery Damage in Stent Deployment
And in-vitro
https://www.sciencedirect.com/science/article/abs/pii/S1742706120304761
And in-vivo
Article Assessment of self-expanding nitinol stent deformation after...
One might find, for a given artery size (and patient age) a range of strain values that correlate to various stages of damage.
Sina,
I've focused on this before, but I haven't found a threshold value of force to describe intima damage. I saw a master's thesis describing 1-2 MPa can cause intima damage, but its citation is not credible. So I won't recommend it.
But this article will hopefully help you out a little bit.
Article Increased artery wall stress post-stenting leads to greater ...
Hello
Currently, my research is focused on how to flow in micro and nano channels and ways to accelerate or increase convective and conductive heat transfer.
However, if I come across such an article among my professors, I will inform you
James Garry Thanks for your reply. Let’s say my application is in the lower limb and above-the-knee arteries (a minimum vessel diameter of ~ 4mm). Any research would be helpful.
I'm interested in research that complements yours, looking at the mechanism of vessel ageing as a function of the force exerted by the stent. This involves characterising the ageing of the vessel and taking into account the characteristics of the blood: pH, viscosity, etc. We would then have a physico-chemical method to calculate the characteristics of the stent adapted to the vessel. This calculation has not yet been validated for biomaterials. IF you are interested in this idea, please contact me.
- Badges
- Science topic