I want to highlight the most important differences between cancer stem cells and more differentiated cancer cells in various tissues whence phenotype , characteristics , behavior of cells , genes , and other things.......
Thanks
Initially due to the actions of a mutagenic/carcinogenic agent when a normal cell is converted into a cell having potential to be divided into a fullfledged CANCER Cell,that cl is the cancer stem cell, from which to originate through cell division process many many cancer cells. many cancer cells form a Cancerous tissue
Is your question asking the difference between cancer stem cells and more differentiated cancer cells or are you asking the difference between malignant and healthy cells?
Tank you Mr . sharrow
my question , asking the difference between cancer stem cells and more differentiated cancer cells ?
There are many differences between the two. Functionally, cancer stem cells (CSCs) are thought to be the originating cells of the cancer and the chemoresistant population. From a clinical standpoint, these may be the most important features. Experimentally, cancer stem cells have an increased tumorigenicity, or ability to grow tumors in immunodeficient mice, over differentiated cancer cells. CSCs are able to survive and grow in higher doses of chemotherapy drugs and after exposure to radiation. There is also some evidence that they are more resistant to immunotherapy approaches. Some say that CSCs are a more quiescent cell population. As for differential gene expression between the two populations, that seems to vary based on which cancer you are talking about. If you do a PubMed or Google Scholar search for cancer stem cells and the cancer you are interested in, you'll likely get numerous papers that describe differential gene expression. The ones that are specifically used for their isolation, or for which there may be a readily available therapeutic target are likely the most important.
Hope that helps,
Dr. Sharrow
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