Hello
A possible risk of some stem cell treatments may be the development of tumors or cancers. For that and through clinical trials , What are the mechanisms lost during growth and affect on behavior these cells ( in vivo or in vitro ) .
Thanks
Dear Saleh,
there are sveral studies regarding cancer stem cells and tumor origin, nevertheless still far from complete answer. Stem cell based therapy exploit mainly adult stem cells, with a well controlled cariotype and with a relative lower proliferation capability exactly to avoid uncontrolled moltiplication and tumor formation.
This is the link regarding stem cell therapy for muscular dystrophy:
http://embomolmed.embopress.org/content/7/12/1513.long
Regards
Cesare
I think that the problem of interest is that the differentiation of stem cells is controlled by their neighboring differentiated tissues. Thus, when stem cells are injected into an animal, it becomes critical where they go and if they find a normal niche site (microenvironment). We have shown that planarians develop teratomas when regeneration is stimulated under conditions where tissues not normally in contact with each other do come into contact. The teratoma contains stem cell derived normal differentiated cells, just in the wrong places, and they call for differentiation of more like cells, also in the wrong places. Such fissiparous planarians can divide away from the tumor, and have no more than the normal incidence of further such tumors, i.e., there is no malignancy in this situation. The caudad remainder, after another fission of so, can no longer support the huge mass and dies. We showed this in 1965 and still in the 1990s and later stem cell injections are made in patients with no control of where they go or the niche in which they will land.
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