Through the research , was to identify the many types of cancers arising from the cancer stem cells , Will these cells have the same signal paths in different cancerous tissues or this cellular tracks vary from cancerous tissue to another
Regards
This is a challenging question, but I would like to give some speculative opinion.
Many researchers believe that cancer stem cells (CSCs) are derived from normal tissue stem cells, which is why the signal transduction or oncogenic driver mutations which CSCs strongly rely on (generally referred to "oncogene addiction") are different among the different tissues or organs.
For instance, nuclear Gli-1/2 activation is necessary for the normal development of both granule precursor cells in the brainstem and hair germ cells and furthermore, not a few patients with medulloblastoma in the cerebellum basal cell carcinoma in the skin exhibit aberrant Shh signal pathway.
On the otherhand, intestinal stem cells localized in the crypt require the activation of beta-catenin/Wnt canonical pathway in cooperation with mTORC1 pathway supported by niche cells called Paneth cells. The inactivation of APC gene results in the nuclear accumulation of beta-catenin and the calorie restriction causes the change in mTOR signal activity, all of which increase the number of malignant transformed-stem cells.
as cancers cells always have mitogenic pathways activated. therefore you have to explore the pathways involved in mitosis for example, MAPK Pathway, Wnt-beta catenin pathway etc
This is a challenging question, but I would like to give some speculative opinion.
Many researchers believe that cancer stem cells (CSCs) are derived from normal tissue stem cells, which is why the signal transduction or oncogenic driver mutations which CSCs strongly rely on (generally referred to "oncogene addiction") are different among the different tissues or organs.
For instance, nuclear Gli-1/2 activation is necessary for the normal development of both granule precursor cells in the brainstem and hair germ cells and furthermore, not a few patients with medulloblastoma in the cerebellum basal cell carcinoma in the skin exhibit aberrant Shh signal pathway.
On the otherhand, intestinal stem cells localized in the crypt require the activation of beta-catenin/Wnt canonical pathway in cooperation with mTORC1 pathway supported by niche cells called Paneth cells. The inactivation of APC gene results in the nuclear accumulation of beta-catenin and the calorie restriction causes the change in mTOR signal activity, all of which increase the number of malignant transformed-stem cells.
This is a good and also an important question. As noted above, cancer stem cells maybe derived from normal stem cells. The most developed field in characterizing stem cells is characterization of leukemia stem cells. It has been shown that refractory leukemia arises from a clone that is usually present at the time of diagnosis although it may represent only a small minority of cells at that time. With treatment, the chemotherapy-sensitive cells die, allowing the more resistant cells to emerge.
Stem cells and cancer stem cells often have activation of various signaling pathways. They may have activation of networks that are typically active in early stem cells such as the homeotic proteins and associated pathways. Oncology textbooks on Cancer, such as deVita, have introductory chapters explaining some of the details. You will have to do an update, but the textbooks have the most practical overviews to start.
Geo datasets, such as:
http://www.ncbi.nlm.nih.gov/gds/?term=cancer+stem+cells
have expression analyses which you can download and examine in a program such as cytoscape. All of this is free. I would compare the expression data from the cancer stem cells with that from normal cells. There is more data all the time, so if you don't see what you want, check back in six months.
You could also do analyses of the signal activation between cancer and normal cells and there are some articles on this as well as thousands of articles looking at pathways. Here is a pathway database: http://pid.nci.nih.gov/. There are others that you can find by seaching "signaling pathways database" or related terms.
LB
- Badges
- Science topic