Can anyone provide papers or links to research conducted with supplementation of antioxidant vitamins A, C or E in humans with Metabolic Syndrome?
Thanks
It seems currently there is no study published on the effect of vitamin A, C or E supplementation on metabolic syndrome. However, some observational studies provide evidence on the relationships.
A study by Godala et al on postmenopausal women with metabolic syndromes found that the optimal dietary intake levels of vitamin A, C and E was only observed in 3.6%, 8.9% and 11.4% of the patients respectively, implying supplementation may be prescribed to improve their vitamin status. (Reference: Article Should antioxidant vitamin supplementation be applied in pat...
) Similar finding was reported on the relationship between low plasma vitamin A, C and E levels and metabolic syndrome in patients by the same research team. (Reference:Article The risk of plasma Vitamin A, C, e and D deficiency in patie...
) Please note that both are case-control study, which cannot prove the cause-and-effect relationship.Apart from the research by Godala et al, we can find some preliminary evidence describing school-age children patients with metabolic syndroms had higher risk of having vitamin A insufficiency. (Reference: Article Serum vitamin A status is associated with obesity and the me...
) Another cross-sectional study also showed high vitamin C intake reduces metabolic syndrome incidence. (Reference:Article Physical activity, dietary vitamin C, and metabolic syndrome...
) But all these are cross-sectional studies, which cannot prove the cause-and-effect relationship.For vitamin E, current review suggests it is a potential intervention treatment for metabolic syndrome. You may refer to the reference: Article Vitamin E As a Potential Interventional Treatment for Metabo...
Hope my answer helps you. Thanks.
Hi Terun
There seems to be dearth of data on supplementation of antioxidant vitamins in metabolic syndrome patients. However, in one study (link below) I have found that the concentration of several antioxidants (vit. A, C, E) is sub-optimal in adults with metabolic syndrome. This may partially explain their increased likelihood of having cardiovascular diseases and diabetes mellitus
http://diabetes.diabetesjournals.org/content/52/9/2346.short
Hi
get a look here:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7916302&fulltextType=RA&fileId=S1368980010002636
Article Effect of Vitamins A, C, and E Supplementation in the Treatm...
Please have a look this review papers
1.Godala M, Materek-Kuśmierkiewicz I, Moczulski D, Rutkowski M, Szatko F, Gaszyńska E, Kowalski J.Estimation of plasma vitamin A, C and E levels in patients with metabolic syndrome].Pol Merkur Lekarski. 2014 May;36(215):320-3.
2.Godala M, Materek-Kuśmierkiewicz I, Moczulski D, Rutkowski M3, Szatko F, Gaszyńska E, Tokarski S, Kowalski J. The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study. Adv Clin Exp Med. 2017 Jul;26(4):581-586. doi: 10.17219/acem/62453.
3.L. S. Bilbis, S. A. Muhammad, Y. Saidu, and Y. Adamu, “Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats,” Biochemistry Research International, vol. 2012, Article ID 678582, 7 pages, 2012. https://doi.org/10.1155/2012/678582.
4.Małgorzata Godala, Izabela Materek-Kuśmierkiewicz, Dariusz Moczulski, Maciej Rutkowski, Franciszek Szatko4, Ewelina Gaszyńska, Sławomir Tokarski5, Jan Kowalski. The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study; Advances in Clinical and Experimental Medicine, ISSN 1899-5276 (print), ISSN 2451-2680 (online).
5.Earl S. Ford, Ali H. Mokdad, Wayne H. Giles and David W. Brown. The Metabolic Syndrome and Antioxidant Concentrations; Diabetes 2003 Sep; 52(9): 2346-2352.
6.MingjingGao,ZhenZhao,PengyuLv,YuFangLi, JuntaoGao, MichaelZhang, BaoluZhao.Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress; Redox Biology;Volume 6, December 2015, Pages 206-217
7.Garcia-Bailo et al. Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress; Biologics: Targets & Therapy 2011:5 7–19
8.Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad and Soelaiman Ima-Nirwana; Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies; Pharmacol., 05 July 2017 | https://doi.org/10.3389/fphar.2017.00444
Please have a look at the following RG links.
Article Should antioxidant vitamin supplementation be applied in pat...
Article Effect of Vitamins A, C, and E Supplementation in the Treatm...
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