Is there a database containing levels of key oncoproteins in diverse breast cancer cell lines?

We are investigating myc inhibitors in breast cell lines and would like to relate response to cellular myc levels.

11 December 2019 4,186 2 View

Any data available on myc amplification/overexpression in breast cancer cell lines?

We are hoping to investigate myc inhibitors in breast cancer and would thus like to know the myc status of different breast cancer cell lines.

06 July 2018 5,539 0 View

What are the best triple-negative breast cancer cell lines for growing as xenograft models?

We are interested in investigating new treatments for triple negative breast cancer.

31 December 2015 2,380 6 View

What are the best antibodies for detecting ER-beta? Which breast cancer cells lines best express ER-beta at the protein level?

Many of the early antibodies against ER-beta has questionable specificity.

07 August 2015 3,460 5 View

What are the breast cancer cell lines with wild-type p53?

We are looking for breast cancer cell lines expressing wild-type p53. Any suggestions?

10 November 2013 1,715 6 View

What is the best triple-negative cell line for testing new drugs in an xenograft model?

We are hoping to test a new drug for triple-negative breast cancer in a suitable animal model. What triple-negative cell line should we use? Thank you

01 January 1970 5,151 8 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

No title

02 March 2021 3,060 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

How does Scientist/RG community evaluates a case study article and the impact of it on a researcher career?

An article that is published as a case study in the SJR listed journal. How much value is added to a researcher career? How it is evaluated by a scientific researcher/University admission...

02 March 2021 9,661 3 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View