We are interested in investigating new treatments for triple negative breast cancer.
We do MDA-MB-231 xenografts commercially (http://altogenlabs.com/xenograft-models/breast-cancer-xenograft/mda-mb-231-xenograft-model/) and they are generally successful. They do take over a month to run, but with starting matrigel injections the tumors are consistent and the growth curves are nice as well.
Dear Michael,
Check this out and consult the authors here on RG:
Article Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, S...
Personally I have had great success with MDA-MB-231. This is a review on the topic:-
Triple Negative Breast Cancer Cell Lines: One Tool in the Search for Better Treatment of Triple Negative Breast Cancer
Kathryn J. Chavez, Sireesha V. Garimella, and Stanley Lipkowitz
Breast Dis. 2010; 32(1-2): 35–48.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532890/
We have used MDA-MB-231s extensively and found them to be reliable. We have implanted them ID, SC and by intracardiac delivery for micrometastases development, and colleagues have implanted them orthotopically with great success. Also, with several clones available that express different reporter genes, you have lots of possibilities for non-invasive monitoring of tumour development.
We do MDA-MB-231 xenografts commercially (http://altogenlabs.com/xenograft-models/breast-cancer-xenograft/mda-mb-231-xenograft-model/) and they are generally successful. They do take over a month to run, but with starting matrigel injections the tumors are consistent and the growth curves are nice as well.
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