Aging is a complex biological process whereby the functional capacity of the body diminishes with time, ultimately leading to the death of the individual. However, aging is also associated with the onset of many diseases, including cancer, Therefore, it is of chief importance to understand if there is a relationship between aging and cancer stem cells.
Cancer cells constantly appear in body and are eradicated by immune surveillance. T-cell function declines over age and hence cancers (and cancer stem cells) show up over age. Its an over simplified statement.
Links of published articles relevant to the issue are provided below:
1.Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation. Cell Reports, 2014; DOI: 10.1016/j.celrep.2014.06.031
2. Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo.
http://www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900134-2
“In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.” “Mutations in low-risk MDS originate exclusively in distinct and rare MDS stem cells.”
3. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
Science, 2014; 345 (6193): 216 DOI: 10.1126/science.1253533
Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the isolation, ex vivo culture, and characterization of CTCs may provide an opportunity to noninvasively monitor the changing patterns of drug susceptibility in individual patients as their tumors acquire new mutations.
4. Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor. Cell Stem Cell, 2014; DOI: 10.1016/j.stem.2014.07.013 .
Thanks of all
And the more importantly we determine the pathways which regulates senescence , and cancer stem cell maintenance.
If you look at he papers on heterochonic parabiosis they indicate that it is the niche rather than the stem cell ages!
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