How DNA methylation play role in cancer ?

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Muhammad Awais

Methylation is one epigentic control of gene expression that sometimes mimic the expression of mutations in the Tumor supressor genes (TSGs)or in the promoter regions of TSGs. So, changes in methylation patteren may lead to the cancer.

Eman El-Abd

Methylation pattern differs during development and in health and disease. It acts as a regulatory mechanism for gene expression and chromatin modelling which change in cancer. This paper might help you.

Nat Rev Genet. 2016 May;17(5):284-99. doi: 10.1038/nrg.2016.13. Epub 2016 Mar 14.

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.

Feinberg AP1, Koldobskiy MA1, Göndör A2.

Ahmed Mansour Alzohairy

This video in Arabic about Methylation iepigentic control of gene expression. I hope you find it useful

https://www.youtube.com/watch?v=wafUlgP7JJ8