My research question is about a protein that is a homo dimer (Two monomer units having chain A and B respectively) Now, we are trying to see the mutational effects in both monomers (same residual position) at the same time (chain A and B respectively). But when I am giving input in DynaMut2 for both the chains then it gives an error while when I give the input for single chain A or B having multiple (two positions) mutations (within the same or single chain) it gives me an output (result) file. so Through this what I can conclude is that DynaMut2 only identifies multiple mutational effects in a single chain OR in other words it is not designed to identify multiple mutational effects belonging to different chains. Please help me to fix this problem.
yes dynamut take only one single chain of protein as a quarry and you can get results for the multiple SNPs for that particular chain. meanwhile if you also wants to get results for the second chain of that protein then you have to mention name of that particular chain. Quarry for both chains will be submitted separately
yes Surinder Pal is correct , to check effect of the mutations on two different chains wont be possible in DynaMut , u need to submit them separately.
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Biomolecules
- Nucleic Acids
- RNA
- Small RNA
- microRNA