i need a cancer cell line can express P-glycoproteins and also be susceptible to Doxorubicin.
Several studies have indicated that high P-gp expression is correlated with enhanced resistance to dox. However, dox-sensitive metastatic MDA-MB-231 and highly metastatic 4T1 breast cancer cell lines can be considered. It should be noted that dox-susceptible cell lines might exhibit a decreased P-gp expression as seen in MCF-7 where, the degree of dox and taxol resistance was significantly proportional to P-gp expression.
Tumor cells with high level of P-gllycoprotein expression tend to be resistant to anti-cancer drugs via the efflux from the cytosol. For instance, HepG2 cancer cell line is reproted to express enahnced level of P-glycoprotein much the same as brain tissue including blood-brain-barrier (BBB).
Given that normal tissue of brain and liver exhibit high level of detoxification and drug deliver from the cytosol in the aggressive manner, hepatic cancer cells and astrocytoma cell lines (after all, astrocytes consist of BBB...) are expected to highly express P-glycoprotein as compared with other kinds of tumor cells.
Hepatic cancer cell lines: HuH-7, HepG2, SK-HEP-1
Astrocytma cell lines: CCF-STTG1, U251MG, U87MG
Article Characterization of a side population of astrocytoma cells i...
Article ABC transporters in cancer: More than just drug efflux pumps
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