i need to polymerize the isopropylmethacrylamide monomers to get a polymer with LCST around 37C. i read in some articles which said it depends on polymer molecular weight.
Dear Sayed Mohammed,
what do you need exactly to know since the literature covering its polymerization is really huge. Regards
if you are looking to get a homopolymer with the monomer then you can try a molecular weight of about 4-5000 g/mol.
if you do not need to have one component,then you can go for a co-polymer approach. i would suggest that you copolymerise nipam and acrylamide. adjust the ratio until you get what you want. nipam has an lcst of 32 deg C. so you might want to try a random copolymer with nipam/acrylamide ratio of 9/1 first. the simplest way to do it is to use aibn with a conventional radical polymerisation method. if you desire more control, you can consider using RAFT. let me know if you have problems.
thank you for your informative answer. actually i need to polymerize it as a homopolymer to get LCST around 37 (36-41)C. i think that LCST you mentioned belongs to isopropylacrylamide. am i right? but i have isopropylmethacrylamide in my hand. but i think the method must be same.
a report showed different molecular weight chain, have different LCST; from 38 to 45C. please find it as attachment. also i attached some articles about this topic; but they use different methods.
by the way, can i mix isopropylmethacrylamide and isopropylacrylamide as a copolymer to get LCST around 37C?
http://onlinelibrary.wiley.com/enhanced/doi/10.1002/masy.201000149/
http://pubs.acs.org/doi/full/10.1021/ma0003102
http://onlinelibrary.wiley.com/doi/10.1002/pola.24979/full
Dear all,
the presence of an additional methyl group render it more hydrophobic, which means the solubility needs additional energy input: From this the slight shifting in LCST may be expected. I think the introduction of a minor amount of acrylamide may rectify the LCST to the needed range. Regards
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