Cancer cells have different abnormalities, like mutation or depletion of tumor suppressor proteins, as well as oncogene activation. In many cases cancer cells have amplified genes which make them tumorigenic. One typical example is c-Myc oncogene, .....amplified in myeloid leukemic HL-60 cells (almost 30 times more than normal level),... which halts the differentiation process in these cells. Can some one please give me a short explanation or a reference to some material that would explain how oncogenes are amplified in cancer cells?
See review article, molecular origins of cancer, oncogenes and cancer by Carlo M. Croce available in full at http://www.nejm.org/doi/full/10.1056/NEJMra072367 or N Engl J Med 2008; 358:502-511January 31, 2008
It has a good review of growth factors and transcription affecting oncogenes and their development. It has also a good list of references from which you can find more articles according to your need.
Anu Makela....Thank you so much...Much has been presented in a compact form in the above referred article...Thanks again.......
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