Would adipogenesis occur if you were to inject freshly isolated pre-adipocytes from human adipose tissue? There are a lot of studies that say it will but I just wanted to ask someone here in simple form.
Yes, for better information you can go through the article attached
Proc. Natl. Acad. Sci. USA
Vol. 95, pp. 1062–1066, February 1998
Cell Biology
De novo adipogenesis in mice at the site of injection of basement
membrane and basic fibroblast growth factor
NOBUKO KAWAGUCHI*, KAZUHIRO TORIYAMA†, ELENI NICODEMOU-LENA*, KAZUHIKO INOU†, SHUHEI TORII†,
AND YASUO KITAGAWA*‡
*Laboratory of Organogenesis, Nagoya University BioScience Center, Chikusa, Nagoya 464-01, Japan; and †Department of Plastic and Reconstructive Surgery,
Nagoya University School of Medicine, Showa, Nagoya 466, Japan
Edited by Kai Simons, European Molecular Biology Laboratory, Heidelberg, Germany, and approved November 21, 1997 (received for review
September 15, 1997)
ABSTRACT Autografting of fat pads has a long history in
plastic and reconstructive surgery for augmentation of lost
soft tissue. However, the results are disappointing because of
absorption of the grafts with time. The fate of transplanted fat
is linked to adipose precursor cells distributed widely in
connective tissues. Adipocyte precursor cells can proliferate
and mature into adipocytes even in the adult body depending
on microenvironment. When reconstituted basement membrane,
Matrigel, supplemented with more than 1 ngyml bFGF
was injected s.c. into 6-week-old mice, the neovascularization
induced within 1 week was followed by migration of endogenous
adipose precursor cells, and a clearly visible fat pad was
formed. The pad grew until 3 weeks after the injection and
persisted for at least 10 weeks. Such de novo adipogenesis was
induced reproducibly by s.c. injection of Matrigel and bFGF
over the chest, lateral abdomen, or head. Adipogenesis could
be induced even in ear cartilage or in muscle. Thus, our results
demonstrated that an abundant population of adipose precursor
cells is distributed widely in connective tissues of the
adult body and that they migrate into the neovascularized plug
of Matrigel for proliferation and maturation. These results
suggest a technique of augmenting lost soft tissue in plastic
and reconstructive surgery.
The answer is yes, you know that pre-adipocyte has a potential stem cell capability, so it should be differentiate and develop adipogenesis. Good luck!
- Badges
- Science topic